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While direct evidence linking the RARA::RXRA and RARA::RXRG complexes to CCL11 expression in the CNS is currently not well established, it is plausible to speculate that retinoic acid signaling through these complexes could inhibit CCL11 expression in specific brain conditions

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20% of the over 60s are deficient in B12, and 11% of those who follow a vegan diet are also deficient The most common cause of Vitamin B12 deficiency is pernicious anaemia, however, it is estimated that 20% of the over 60s are deficient in B12, and 11% of those who follow a vegan diet are also deficient